|
KMID : 0665220220350030178
|
|
Korean Journal of Food and Nutrition
2022 Volume.35 No. 3 p.178 ~ p.184
|
|
|
[10]-Gingerol Induces Intrinsic Apoptosis in A2058 Human Melanoma Cells
|
|
Guon Tae-Eun
Chung Ha-Sook
|
|
|
Abstract
|
|
|
|
The objective of the present study was to investigate the molecular mechanisms involved in the activity of [10]-gingerol using A2058 human melanoma cells. [10]-Gingerol inhibited the proliferation of A2058 cells by 50% at a concentration of 52 μM. Such inhibition was dose-dependent accompanied by morphological change indicative of apoptosis. Furthermore, flow cytometric analysis by Annexin V and PI double staining showed that [10]-gingerol increased the extent of apoptosis. Analysis of the mechanism of these events indicated that [10]-gingerol increased the ratio of Bax to Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner.
|
|
|
KEYWORD
|
|
|
[10]-gingerol, Zingiber officinale Roscoe, A2058, human melanoma cells, intrinsic apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|